メインコンテンツに移動
  • 認定パートナー
  • ELGAについて
    • ELGAについて
    • 採用情報
    • イベント
  • サポート
    • ラボのプランニング
    • 製品を登録
    • Register Your Product (USA & Canada Only)
  • お問い合わせ
  • U.S.A.
  • U.K.
  • Deutschland
  • España
  • France
  • Italia
  • Brasil
  • 中国
ホーム ELGA LabWater
  • 製品
    • PURELAB
    • CENTRA
    • MEDICA
    • BIOPURE
    • ELGA全製品ライン
  • 用途
    • ガスクロマトグラフィー
    • ラボ用水の一般要件
    • 免疫組織染色
    • 分光測光法
    • 原子分光学
    • 微生物学的分析
    • 液体クロマトグラフィー
    • 細胞培養
    • 臨床生化学
    • 質量分析
    • 遺伝学
    • 電気化学
  • 純水製造技術
    • PureSure
    • ろ過
    • イオン交換
    • 活性炭
    • 紫外線
    • 逆浸透(RO)
    • 電気脱イオン処理(EDI)
  • 水中の不純物
    • 微生物&細菌
    • 有機化合物
    • 溶存ガス
    • 無機化合物
    • 粒子状物質
  • Knowledge
    • ブログ
    • ケーススタディ
    • 超純水
    • ガイド&ホワイトペーパー
  • 製品
    • PURELAB
    • CENTRA
    • MEDICA
      • Hubgrade
      • MEDICA BIOX
    • BIOPURE
    • ELGA全製品ライン
      • PURELAB® Classic
  • 用途
    • ガスクロマトグラフィー
    • ラボ用水の一般要件
    • 免疫組織染色
    • 分光測光法
    • 原子分光学
    • 微生物学的分析
    • 液体クロマトグラフィー
      • Hochleistungsflüssigkeitschromatographie (HPLC)
    • 細胞培養
    • 臨床生化学
    • 質量分析
    • 遺伝学
    • 電気化学
  • 純水製造技術
    • PureSure
    • ろ過
    • イオン交換
    • 活性炭
    • 紫外線
    • 逆浸透(RO)
    • 電気脱イオン処理(EDI)
  • 水中の不純物
    • 微生物&細菌
    • 有機化合物
    • 溶存ガス
    • 無機化合物
    • 粒子状物質
  • Knowledge
    • ブログ
      • Analytical Chemistry
      • Clinical & Pharma
      • Cool Science
      • Environment and sustainability
      • Life in the lab
      • Purelab product design
      • Science of the future
      • Water Purity
      • Water in the lab
    • ケーススタディ
      • 南アジアのAbbott Diagnostics、ELGA MEDICAシステムを選択
      • Beam Me Up, Scotty: PURELAB® Option Q Delivers Essential Ultra Pure Water
      • Argenta chooses DKSH New Zealand to deliver Ultrapure water in Animal Pharma
      • Clean Water for a Clean Future
      • LS Scientific & ELGA deliver UltraPure water to the NAFDAC Laboratory
      • Lifebrain Group chooses ELGA as water partner for new modern 24/7 PCR-COVID-19 laboratory in Vienna, Austria.
      • Critital Tests Benefit from PURELAB® Option Reliable Pure Water
      • DASA:ブラジル最大の医療診断企業
      • 免疫血清学ラボの稼働時間最大化を支援するELGA
      • Fondazione Telethon Continues to Choose ELGA Labwater as a Trusted Partner
      • ジェネリック医薬品開発における超純水(I型水+)の重要性
      • Siemens ADVIA分析装置用に市立総合病院がMEDICA®Proを導入
      • Optimale Wasserqualität für mikrobiologische Forschung und Lehre
      • PURELAB® Option R Guarantees Pure Water for Leading Microfluidics Technology
      • PURELAB® Pulse Delivers Reliable Water Quality and Quantity for a Wide Range of Applications
      • PURELAB® flex:現代的な研究手法における理想的なトレーニングシステム
      • Powering Cutting-Edge Gene Research
      • Sichere Reinstwasserversorgung für präzise Produkttests
      • Zentrale Reinstwasser-Aufbereitung für Analyser
      • ELGA LabWater and Beckman Coulter Join Forces
      • Applied New Technologies Department Improves ICP, IC & HPLC Sample Turnaround Times with PURELAB®
      • 超純水により南極の謎を解明
      • Advancing Genetic Technologies
      • Cross Infection Control: Pure and Simple
      • Researching effective new ways to prevent cardiovascular disease at the University of Columbia
    • 超純水
    • ガイド&ホワイトペーパー
      • HPLC用水の純度
      • 製薬におけるHPLC
      • 臨床でのリスクの低減
      • サステナビリティ
  • U.S.A.
  • U.K.
  • Deutschland
  • España
  • France
  • Italia
  • Brasil
  • 中国
  • プライバシーポリシー
  • 利用規約
  • 世界的な法令順守
  • 特許
  • サイト管理者情報
  • ホーム
  • The Danger of Designer Benzodiazepines
Clinical & Pharma
Analytical Chemistry

The Danger of Designer Benzodiazepines

20 12月 2021
- by Dr Alison Halliday

Young depressed man sitting on floor

A case study of a fatal intoxication highlights the public health risk of ‘legal high’ substances that are commonly sold without effective restriction.

Designer benzodiazepines (DBZDs) are a class of novel psychoactive substances that have recently emerged onto the recreational drug market. They are commonly sold on the internet without restrictions at relatively low prices – or added to counterfeit products of approved benzodiazepines (BZDs), which are central nervous system (CNS) depressants used to treat anxiety and insomnia.

The European Monitoring Centre for Drugs and Drug Addiction is currently monitoring 30 DBZDs, 21 of which have entered the market since 2015. Up to now, data regarding the safety, toxicity, and potency of these substances is largely missing. Therefore, they represent a potential public health problem with a high risk for unintended intoxications and fatalities, especially when combined with other CNS depressants.

Flualprazolam is a novel DBZD that appeared on the market for the first time in 2017. It has since been seized as tablets, ‘blotters’ or in powder form in many European countries. But currently, there is very little known about the pharmacokinetics and pharmacodynamics of this novel psychoactive substance.

A Fatal Intoxication

A new report, published in Forensic Toxicology, describes a case of fatal multidrug intoxication involving flualprazolam.1 In February 2019, a 21–year–old male with a history of drug abuse, was found lying unresponsive on his bed. He was immediately brought to hospital and resuscitated but was declared dead approximately two hours later. 

Blood samples taken at the hospital and during a complete postmortem examination were available for analysis. General unknown screenings and analysis of drugs of abuse on postmortem samples were performed using immunoassay, gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS) analyses. The scientists used deionised water prepared from an ELGA Medica® Pro deioniser, minimising the risk of adding contaminants that might affect the results of these sensitive analytical techniques.

The forensics team detected flualoprazolam in heart serum (25.4 ng/mL) and peripheral blood (21.9 ng/mL) as well as in urine, stomach contents, brain, liver and kidney. The cause of death was deemed as CNS and respiratory depression with the agonal aspiration of stomach contents. Given the concentrations of the co–consumed CNS depressants, the contribution of flualoprazolam to the death was considered likely (with a toxicological significance score of 3).

A Public Health Warning

These results support the hypothesis that highly potent DBZDs, like flualprazolam, carry an elevated risk for unintended toxicity, especially in combination with other CNS depressants that act to slow down brain activity. 

A comprehensive evaluation of fatalities remains mandatory, especially when there is a lack of pharmacological and toxicological data on intoxicating compounds. Given the potential for fatal intoxications, particularly when combined with other CNS depressants, their easy availability at relatively low prices and the elevated risk of unintended overdoses, DBZDs deserve increased attention from a public health perspective.

Why Choose ELGA LabWater?

ELGA LabWater has been a trusted name in pure and ultrapure water since 1937. We believe in giving you choice in how you use our water purification solutions, supported by excellent service and support.

 

Reference:

  1. Giorgetti, A. et al. A case of fatal multidrug intoxication involving flualprazolam: distribution in body fluids and solid tissues. Forensic Toxicol (2021) https://doi.org/10.1007/s11419-021-00591-w


Dr Alison Halliday

After completing an undergraduate degree in Biochemistry & Genetics at Sheffield University, Alison was awarded a PhD in Human Molecular Genetics at the University of Newcastle. She carried out five years as a Senior Postdoctoral Research Fellow at UCL, investigating the genes involved in childhood obesity syndrome. Moving into science communications, she spent ten years at Cancer Research UK engaging the public about the charity’s work. She now specialises in writing about research across the life sciences, medicine and health.

risk whitepaper

When lives are at stake, there is no margin for error. Your clinical analyser must receive a constant and reliable supply of CLRW. 

Find out how to protect your test results

                   Click Here

 

  • Enquiry
  • 見積もりを取得
  • デモを予約する
  • 承認されたパートナーを見つける

Enquiry

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

見積もりを取得

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

デモを予約する

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Call us

Can't find what you are looking for?

Support Number
+44 (0)20 3567 7300
United Kingdom Sales
+44 (0)1628 879 704
United States of America Sales
+1 877-315-3542
France Sales
+33 1 40 83 65 00
China Sales
+86 400-616-8882

 

ELGA LabWater US Headquarters

Lane End Business Park
Lane End, High Wycombe
HP14 3BY
United Kingdom
電話: +44 (0) 203 567 7300
ファックス:+44 (0) 203 567 7205

ELGA LabWater本社

Lane End Business Park
Lane End, High Wycombe
HP14 3BY
United Kingdom
電話: +44 (0) 203 567 7300
ファックス:+44 (0) 203 567 7205

ケーススタディ

  • Abbott Diagnostics(アボットダイアグノスティクス)
  • DASA Medical Diagnostics(DASA医療診断)
  • NeoDIN Medical Institute(NeoDIN医療機関)
  • UHNS(University Hospital of North Staffordshire NHS Trust/北スタンフォードシャア大学病院)
  • Olsberg Vocational College(オルスバーグ専門学校)

リソース

  • 超純水について
  • ガイド&ホワイトペーパー
  • 純水製造技術
  • 用途
  • 水中の不純物

Blogs

  • Latest Blog
  • Water Purity - Different Types of Pure Water
  • What is Clinical Laboratory Reagent Water (CLSI)?
  • What is Total Organic Carbon (TOC)?
  • 言語
    • Deutsch
    • English
    • Español
    • Français
    • Italiano
    • Português
    • 日本語
    • 中文
  • 他のVeoliaサイト
    • Veolia
    • Veolia Foundation
    • Veolia Water Technologies

©VWS(UK)Ltd.はELGA LabWaterとして取引されています。2023-全著作権所有。
ELGAはVeoliaのグローバルなラボ用水のブランド名です。

  • プライバシーポリシー
  • 利用規約
  • 世界的な法令順守
  • 特許
  • サイト管理者情報
Elga Veolia
TOP

© 2017 ELGA Veolia